Contribution of derivatization in gas chromatography

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Some points on contribution of derivatization in gas chromatography are:

  • Derivatization reduces injector-induced degradation by shielding reactive sites from high-temperature exposure.
  • It stabilizes analytes during rapid heating by forming derivatives that withstand thermal shock at injection.
  • Derivatization lowers the formation of breakdown products by limiting heat-driven side reactions during analysis.