Advantages and Disadvantages of Gas Liquid Chromatography GLC

Some advantages and disadvantages of gas liquid chromatography are discussed below. So let us check out its advantages and disadvantages to know more about gas liquid chromatography.

Some Advantages of Gas Liquid Chromatography GLC are :

1. Gas liquid chromatography offers high sensitivity, precision and resolving power for analyzing a wide range of analytes.
2. Detects trace amounts of analytes with high sensitivity.
3. Excellent resolving power for complex mixtures.
4. Accurate and precise quantitative analysis.
5. Wide range of analytes can be analyzed.
6. High speed of analysis.
7. Capable of identifying and quantifying volatile compounds.
8. Minimal sample preparation required.
9. High reproducibility and precision of results.
10. Can be coupled with mass spectrometry for identification.
11. Non-destructive analysis for sample preservation.

Some Disadvantages of Gas Liquid Chromatography GLC are :

1. Gas liquid chromatography is Limited to volatile and semi-volatile compounds.
2. Compounds must be thermally stable and volatile.
3. Non-volatile compounds are not detected.
4. High boiling point compounds not easily separated.
5. Limited application to non-polar and semi-polar compounds.
6. Can't separate large molecules such as proteins.
7. Possibility of column overload with complex samples.
8. Sensitivity to impurities in the sample matrix.
9. Column stationary phase can degrade over time.
10. Solvents and reagents can cause column damage.
11. Limited use for chiral separations.

Advantages and Disadvantages of Gas Chromatography (GC)

 Some advantages and disadvantages of Gas Chromatography are discussed below. So let us check it out its advantages and disadvantages to know more about gas chromatography.

Advantages of Gas Chromatography GC are:

1. Gas chromatography has high resolution power compared to other methods.
2. GC has high sensitivity.
3. High peak capacity.
4. Gas chromatography has high accuracy and precision.
5. It can separate complex mixtures.
6. It is used to resolve closely related compounds.
7. Small sample volume can be separated using gas chromatography.
8. Quantitative analysis is possible using GC.
9. GC can be coupled with mass spectrometry.

Disadvantages of Gas Chromatography GC are:

1. Gas chromatography is limited to volatile compounds.
2. Non-volatile compounds don't vaporize.
3. Analyte can decompose at high temperature.
4. Analyte can also react with stationary phase.
5. It is limited to low to medium molecular weight.
6. It is incompatible with aqueous samples.
7. Thermal stability is required during separation through gas chromatography.
8. It is not suitable for high-boiling compounds.
9. It is not sutable for polar analytes. 

How Does Gas Chromatography Work?

Gas Chromatography

Chromatography Types

Gas Chromatography Detectors

What is GC | Gas chromatography?

GAS CHROMATOGRAPHY METHOD

APPLICATIONS OF GAS CHROMATOGRAPHY

GAS CHROMATOGRAPHY ADVANTAGES