Tuesday 7 March 2023

Advantages and Disadvantages of Gas Chromatography (GC)

 Some advantages and disadvantages of Gas Chromatography are discussed below. So let us check it out its advantages and disadvantages to know more about gas chromatography.

Advantages of Gas Chromatography GC are:

  1. Gas chromatography has high resolution power compared to other methods.
  2. GC has high sensitivity.
  3. High peak capacity.
  4. Gas chromatography has high accuracy and precision.
  5. It can separate complex mixtures.
  6. It is used to resolve closely related compounds.
  7. Small sample volume can be separated using gas chromatography.
  8. Quantitative analysis is possible using GC.
  9. GC can be coupled with mass spectrometry.

Disadvantages of Gas Chromatography GC are:

  1. Gas chromatography is limited to volatile compounds.
  2. Non-volatile compounds don't vaporize.
  3. Analyte can decompose at high temperature.
  4. Analyte can also react with stationary phase.
  5. It is limited to low to medium molecular weight.
  6. It is incompatible with aqueous samples.
  7. Thermal stability is required during separation through gas chromatography.
  8. It is not suitable for high-boiling compounds.
  9. It is not sutable for polar analytes. 

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