Difference Between Affinity and Adsorption in Chromatography

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In chromatography, affinity refers to selective binding based on specific molecular recognition, whereas adsorption involves non-specific surface interactions. Affinity depends on complementary structural features between interacting molecules, while adsorption is governed by general physical forces such as van der Waals interactions. This distinction explains why affinity-based interactions provide higher selectivity than adsorption-based interactions in chromatographic analysis.

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