Function of derivatization in gas chromatography

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Some points on function of derivatization in gas chromatography are:

  • Derivatization reduces analyte polarity by neutralizing functional groups that strongly interact with the stationary phase.
  • It increases vapor-phase residence time by forming derivatives that resist condensation during column transit.
  • Derivatization facilitates uniform analyte transfer into the column by producing compounds with consistent volatilization behavior.