Purpose of derivatization in gas chromatography

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Some points on purpose of derivatization in gas chromatography are:

  • Derivatization protects heat-sensitive functional groups by converting them into chemically stable derivative forms.
  • It reduces thermal decomposition by preventing bond cleavage that occurs in native analytes at injector temperatures.
  • Derivatization minimizes analyte degradation during oven heating by forming derivatives with higher thermal tolerance.