Role of derivatization in gas chromatography
Some points on role of derivatization in gas chromatography are:
- Derivatization replaces active hydrogen atoms with nonpolar substituents that raise analyte vapor pressure.
- It converts highly polar compounds into neutral derivatives that can readily enter the gas phase.
- Derivatization reduces strong intermolecular attractions that otherwise limit volatilization under GC conditions.
Also check it out importance of derivatization in gas chromatography to learn more about it.