Role of derivatization in gas chromatography

Some points on role of derivatization in gas chromatography are:

  • Derivatization replaces active hydrogen atoms with nonpolar substituents that raise analyte vapor pressure.
  • It converts highly polar compounds into neutral derivatives that can readily enter the gas phase.
  • Derivatization reduces strong intermolecular attractions that otherwise limit volatilization under GC conditions.

Also check it out importance of derivatization in gas chromatography to learn more about it.