Significance of derivatization in gas chromatography

Some points on significance of derivatization in gas chromatography are:

  • Derivatization introduces silyl, acyl, or alkyl groups that reduce analyte polarity and promote vaporization.
  • It increases analyte compatibility with the carrier gas by forming derivatives that remain in the gas phase during transport.
  • Derivatization enables low-volatility compounds to pass through the injector without condensation.

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