Significance of internal standard in gas chromatography

Some points on significance of internal standard in gas chromatography are:

  • An internal standard undergoes the same sample preparation steps as analytes, allowing correction for preparation-related losses.
  • It experiences identical chromatographic conditions, enabling adjustment for run-to-run variability in retention and response.
  • The internal standard tracks short-term instrumental drift by responding to the same operating changes during analysis.

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