Use of derivatization in gas chromatography

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Some points on use of derivatization in gas chromatography are:

  • Derivatization increases resistance to thermal rearrangement by converting unstable functional groups into fixed derivative structures.
  • It prevents catalytic degradation by reducing interaction between analytes and active metal or glass surfaces at elevated temperatures.
  • Derivatization maintains analyte integrity throughout the temperature program by forming compounds with predictable thermal behavior.