How does GPC calculate molecular weight?

Points on GPC and molecular weight calculation:

  • In GPC or Gel Permeation Chromatography analysis, molecular weight distribution is calculated by comparing sample retention times with polymer standards of known molecular size.
  • Calibration curves are generated using reference polymers with narrow and well-defined molecular weight distributions.
  • These calibration relationships convert chromatographic retention data into accurate number-average and weight-average molecular weight values.

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