How Does Solvent Strength Change Separation in Adsorption Chromatography?

Adsorption chromatography changes separation patterns when the solvent strength alters how tightly substances remain on the stationary phase. A stronger solvent competes more effectively with analyte molecules for active adsorption sites on the solid surface. As solvent strength increases, compounds detach more easily and move faster through the column. Weaker solvents allow stronger surface interactions, causing compounds to remain adsorbed for longer periods. By adjusting solvent strength, analysts can control retention time and fine-tune how clearly different components separate. Also know more about importance of adsorption chromatography to get more details.