Why Does Partition Chromatography Produce Distinct Peaks?

Some points on why does partition chromatography produce distinct peaks:

• Partition chromatography produces distinct peaks for closely related compounds that cannot be resolved by simpler separation techniques.
• Equilibrium-driven partitioning causes slight solubility differences to accumulate as compounds migrate through the column, spreading their elution times.
• This gradual divergence in retention results in clearly defined peaks, even when molecular structures differ only marginally.

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