Why Does Reverse Phase Chromatography Reduce Sample Modification?

Some points on why reverse phase chromatography reduce sample modificaiton:

Reverse phase chromatography allows many organic compounds to be analyzed without prior chemical modification. Numerous analytical techniques require derivatization steps to alter compound properties before separation can occur. The ability to separate substances in their native form simplifies analytical preparation and reduces procedural complexity. This direct applicability enhances the practical value of the method in routine and research laboratories. Also check it out importance of reverse phase chromatography for more details.