What is the contribution of degassing in HPLC?

Some points on contribution of degassing in HPLC are:

• Degassing prevents air bubble entry into the detector flow cell that can cause signal spikes and baseline noise.
• It reduces pump check valve malfunction by eliminating gas bubbles that interfere with valve sealing.
• Degassing maintains stable flow rate by preventing intermittent bubble-induced pressure fluctuations.

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