What is the purpose degassing in HPLC?

Some points on purpose of degassing in HPLC are:

  • Degassing prevents bubble formation by eliminating gas pockets that can expand under reduced pressure in the pump chamber.
  • It avoids flow interruptions caused by bubbles entering the pump head during solvent delivery.
  • Degassing maintains continuous liquid contact in the pumping system, preventing cavitation during high-pressure operation.

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