What is the use of degassing in HPLC?

Some points on use of degassing in HPLC are:

  • Degassing prevents vapor lock by ensuring uninterrupted liquid flow through the pump and solvent lines.
  • It reduces pressure pulsations by eliminating compressible gas pockets within the mobile phase.
  • Degassing protects detector stability by maintaining a continuous, bubble-free flow through the detection cell.

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