What types of substances are separated by ion exchange chromatography?

What types of substances are separated by ion exchange chromatography?

Ion exchange chromatography is designed specifically to separate ionic and ionizable substances based on their electrical charge. Compounds that can form positive or negative ions interact with charged sites on the stationary phase and are selectively retained. Molecules that remain neutral under the operating conditions are not separated, reinforcing the method’s identity as a charge-based technique.

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