Why does solubility control separation in partition chromatography?

Points on solubility control in partition chromatography:

  • In partition chromatography, separation is governed by the unequal solubility of sample components between a stationary liquid phase and a flowing mobile phase. 
  • Each component establishes a different concentration in the two phases at equilibrium, causing unequal retention within the stationary liquid layer. 
  • As the mobile phase advances, components with lower affinity for the stationary phase move forward more rapidly, producing separation along the chromatographic path.

Also find out more information on what is partition chromatography to learn more about it.