Tuesday, 7 January 2014

Basics of Pharmacokinetics and Pharmacodynamics


Basics of Pharmacokinetics and Pharmacodynamics. Parameters and differences between them are listed to understand pharmacokinetics.

Basics of Pharmacokinetics and Pharmacodynamics

Basics of Pharmacokinetics and Pharmacodynamic

Pharmacokinetics  can be simply defined as what the body does to the drug while pharmacodynamics can be defined as what the drugs does to the body"

Pharmacokinetic Parameters are as follows:
Adsorption: 
Parameter 1: Adsorption rate constant- Rate of drug adsorption / amount of drug remaining to be adsorb.
Parameter 2: Bioavailability - Amount of drug adsorbed / drug dose
Distribution: 
Parameter 1: Apparent Volume of Distribution - Amount of drug in the body / plasma drug concentration.
Parameter 2: Unbound Fraction - Plasma concentration of unbound drug / Plasma drug concentration
Elimination:
Parameter 1: Rate of elimination - Renal excretion / extrarenal elimination
Parameter 2: Clearance - Rate of drug elimination / Plasma drug concentration
Parameter 3: Renal Clearance - Rate of renal excretion of drug / plasma drug concentration
Parameter 4: Metabolic Clearance - Rate of drug metabolism / plasma drug concentration
Parameter 5: Fraction Excreted unchanged - Rate of renal excretion of drug / rate  of drug elimination
Parameter 6: Elimination rate constant - Rate of drug elimination / amount of drug in the body
Parameter 7: Biologic half life
Pharmacodynamics is the study of the physiological or the biochemical effect of drug on the body

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