Advantages and Disadvantages of Chromatography

 Some advantages and disadvantages of chromatography are discussed below. So let us check out its advantages and disadvantages to know more about chromatography.

Some Advantages of Chromatography are:

1. Chromatography can separate complex mixtures with great precision.
2. High resolution and sensitivity.
3. It can handle small sample sizes.
4. Fast analysis method.
5. It separate compounds based on their chemical properties. 
6. Different compound moves at different speeds. 
7. It is suitable for a wide range of compounds. 
8. Chromatography can separate isomers and enantiomers.
9. It allows easy quantification.
10. Chromatography is versatile and adaptable to different needs.

Some Disadvantages of Chromatography are:

1. Chromatography method is expensive. 
2. Costly materials and equipments are used.
3. It requires skilled personnel and maintenance.
4. Chromatography needs specific conditions and environments.
5. Initial investment can be high. 
6. Chromatography continuously needs solvents and gases.
7. High energy consumtion during chromatography analysis.
8. Analysis can sometimes be time consuming.
9. Multiple runs may be necessary.

Advantages and Disadvantages of Gas Chromatography (GC)

 Some advantages and disadvantages of Gas Chromatography are discussed below. So let us check it out its advantages and disadvantages to know more about gas chromatography.

Advantages of Gas Chromatography GC are:

1. Gas chromatography has high resolution power compared to other methods.
2. GC has high sensitivity.
3. High peak capacity.
4. Gas chromatography has high accuracy and precision.
5. It can separate complex mixtures.
6. It is used to resolve closely related compounds.
7. Small sample volume can be separated using gas chromatography.
8. Quantitative analysis is possible using GC.
9. GC can be coupled with mass spectrometry.

Disadvantages of Gas Chromatography GC are:

1. Gas chromatography is limited to volatile compounds.
2. Non-volatile compounds don't vaporize.
3. Analyte can decompose at high temperature.
4. Analyte can also react with stationary phase.
5. It is limited to low to medium molecular weight.
6. It is incompatible with aqueous samples.
7. Thermal stability is required during separation through gas chromatography.
8. It is not suitable for high-boiling compounds.
9. It is not sutable for polar analytes.