Saturday 14 June 2014

Limit of Detection in Analytical Method Validation

What is Limit of Detection in Analytical Method Validation?

One of the important parameter is Limit of detection in Analytical Method validation. It is carried out to get accurate, reliable and consistent test result. Limit of detection can be defined as: The smallest quantity of an analyte used in the test that can be detected but not necessarily quantified.

The approaches for calculation of limit of detection are:

  • Signal to noise ratio
  • By visual evaluation
  • By standard deviation of the response
  • Calculated by the slope of the calibration curve.
In chromatography the detection limit  is the injected amount of analyte which results into peak and the limit of detection can be defines as the lowest concentration of sample that can be detected. 

Related Articles on Analytical Method Validation:

  1. Analytical Method Validation
  2. What is Analytical Method Validation Definition
  3. Steps in Analytical Method Validation
  4. What are Analytical Method Validation Parameters?
  5. Ruggedness in Analytical Method Validation
  6. Robustness in Analytical Method Validation
  7. Limit of Quantification in Analytical Method Validation
  8. Limit of Detection in Analytical Method Validation
  9. Range in Analytical Method Validation


Popular Posts